In 1981, Ka-Zar The Savage, written by Bruce Jones, became Anderson’s first regular series. The X-Men: God Loves, Man Kills graphic novel followed, as well as artwork on a number of Marvel Comics series, including the heroic space-opera Strikeforce: Morituri. During this period, Anderson was active doing artwork for independent publishers Pacific Comics and Eclipse Comics, including the innovative cinematic comic Somerset Holmes.
In 1995, Anderson co-created (with writer Kurt Busiek and cover artist Alex Ross), the award-winning Astro City. Other work included J. Michael Straczynski’s Rising Stars: Untouchable spin-off series written by Fiona Avery covering the life story of special assassin Laurel Darkhaven. Work continues on a 200-plus page graphic novel, Jar of Ashes, written by Shirley Johnston. Anderson worked with writer Marv Wolfman on a one-shot featuring Green Lantern and Plastic Man entitled Green Lantern/Plastic Man: Weapons of Mass Deception, released in December 2010. A Phantom Stranger ongoing series written by Dan DiDio and drawn by Anderson began in September 2012. In June 2013, Busiek and Anderson relaunched their Astro City series as part of DC’s Vertigo line.